These studies incorporate the results of mass spectrometry-based peptide mapping to develop a close understanding of ligand-receptor interactions. One of our goals is to utilize this information to design genetically engineered trophic factors with unique functional activity. We are also interested in designing small molecules by using available glutamate receptor crystal structure information. This work is primarily performed on a custom built multiprocessor HP Xeon workstation supporting true hardware 3D. We utilize a variety of software packages, with lab subscriptions to Yasara, Schrodinger suite, MOE, and PyMol.